Label-free silicon-photonics cytometry · application surface
What the chip can tell a clinician — and a bioprocess engineer
Every readout in the tiered biomarker list, mapped to what it would enable — by hardware tier, clinical or industrial setting, and how strong the published evidence is. Start with the full map, or open a focused read on CGT & CAR-T, oncology, or sepsis triage — each split into what is possible and what is not. Tier 1 is the label-free layer (the cartridge lyses with saponin and a stop reagent; no antibodies or dyes); Tier 2 is predicted virtual staining; Tier 3 is the reagent-based roadmap. No chip has been made and no design is verified: every Tier-1 number is simulation-level, and nothing here is on sale. The Tier-1 readouts supportable today are a white-cell count and a blast / abnormal-cell flag; the 3-part differential is the target. Red cells and platelets are lysed before the optics, so every red-cell and platelet readout is blocked until an unlysed side channel is designed — none is.